Since the discovery of the blood group in 1901 by Nobel laureate Karl Landsteiner and the first successful bone marrow transplantation in 1956 by another Nobel laureate, Donnall Thomas, we have come a long way to understanding the fundamental principles of transplantation immunology and clinical transplantation. Hematopoietic stem cell transplantation in primary immunodeficiency disorders, especially in severe combined immunodeficiency (SCID), has been a prime example of progress that this discipline has made and the difficulties it faces. The use of haplocompatible related donors has reduced the length of time required to perform transplantation and has improved the outcome. Similarly, the availability of cord blood stem cells has opened new opportunities. The requirement for precondition…
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