The Alliance for Cancer Gene Therapy (ACGT) is celebrating its 10th anniversary next Thursday, April 19, at 6:30 p.m. with a tribute dinner honoring co-founder the late Edward Netter.Source:
http://news.search.yahoo.com/news/rss?ei=UTF-8&p=gene+therapy&eo=UTF-8
Archive for the ‘Gene therapy’ category
Gene therapy group looks to new frontiers in fight against cancer
April 29th, 2012Video: Gene therapy reverses Parkinson's symptoms: study
April 29th, 2012A new British study has discovered a potentially groundbreaking treatment for Parkinson's disease. Neurosurgeon Dr. Michael Kaplitt speaks to the "CBS This Morning" co-hosts about how gene therapy can reverse Parkinson's symptoms.Source:
http://news.search.yahoo.com/news/rss?ei=UTF-8&p=gene+therapy&eo=UTF-8
New York Mesothelioma Lawyer Applauds Advances in Gene Therapy Cited in New Book
April 29th, 2012Attorney Joseph W. Belluck of New York’s Belluck & Fox, LLP, says a new history of gene therapy presents an optimistic outlook for the future of fighting asbestos exposure diseases.New York, NY (PRWEB) April 19, 2012 New York mesothelioma lawyer Joseph W. Belluck said today that a new book about gene therapy is another sign of hope for mesothelioma sufferers. …Source:
http://news.search.yahoo.com/news/rss?ei=UTF-8&p=gene+therapy&eo=UTF-8
Gene Therapy Restores Sight to Three Patients
April 29th, 2012After several years of setbacks, gene therapy is once again yielding promising results. One area in which it is proving its potential is in restoring vision to patients who have been losing it since birth. [More]Source:
http://news.search.yahoo.com/news/rss?ei=UTF-8&p=gene+therapy&eo=UTF-8
Global Gene Therapy Industry
April 29th, 2012NEW YORK, April 16, 2012 /PRNewswire/ — Reportlinker.com announces that a new market research report is available in its catalogue: Global Gene Therapy Industry http://www.reportlinker.com/p098244/Global-Gene-Therapy-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=BiologicaThis …Source:
http://news.search.yahoo.com/news/rss?ei=UTF-8&p=gene+therapy&eo=UTF-8
Adeno-associated virus-mediated doxycycline-regulatable TRAIL expression suppresses growth of human breast carcinoma in nude mice
April 29th, 2012Conclusion:
These data suggest that rAAV-mediated soluble TRAIL expression under the control of the Tet-On system is a promising strategy for breast cancer therapy. (Source: BMC Cancer)Source:
http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
Epirubicin potentiates recombinant adeno?associated virus type 2/5–mediated TRAIL expression in fibroblast?like synoviocytes and augments the antiarthritic effects of rAAV2/5?TRAIL
April 29th, 2012ConclusionThese results suggest that epirubicin enhances the antiarthritic effect of rAAV2/5?TRAIL and that combination treatment might be an important therapeutic alternative, with practical significance for rheumatoid arthritis. (Source: Arthritis and Rheumatism)Source:
http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
April 29th, 2012In conclusion, adoptive immunotherapy with CD20-specific T cells was well tolerated and was associated with antitumor activity. We will pursue alternative gene transfer technologies and culture conditions in future studies to improve CAR expression and cell production efficiency. This study is registered at www.clinicaltrials.gov as NCT00621452. (Source: Blood)
MedWorm Sponsor Message: Please have a look at this new site driven by MedWorm: The Breast Cancer Daily
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http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
Prospects for gene transfer for clinical heart failure
April 29th, 2012Authors: T Tang, M H Gao
& H Kirk Hammond (Source: Gene Therapy)Source:
http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
Gene therapy for ventricular tachyarrhythmias
April 29th, 2012Gene Therapy advance online publication, April 26, 2012.
doi:10.1038/gt.2012.35
Author: J K Donahue (Source: Gene Therapy)Source:
http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
Activation of a glioma-specific immune response by oncolytic parvovirus Minute Virus of Mice infection
April 29th, 2012Authors: S P Grekova, Z Raykov, R Zawatzky, J Rommelaere
& U Koch (Source: Cancer Gene Therapy)Source:
http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
IL15 combined with Caspy2 provides enhanced therapeutic efficiency against murine malignant neoplasm growth and metastasis
April 29th, 2012Authors: Y Yang, X-m Zhang, N Zhang, L Cheng, C Li, S Zhang, J-f Zhang, L Dai, H-w Tian, N Yan, P Fan, L-x Dai, F Xu, G Shi, X-l Chen, T Du, Y-m Li, Y-Q Wei
& H-X Deng (Source: Cancer Gene Therapy)Source:
http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures.
April 29th, 2012Authors: Turrell SJ, Macnab SA, Rose A, Melcher AA, Whitehouse A
Abstract
Herpesvirus saimiri (HVS) is capable of infecting a range of human carcinoma cell types with high efficiency and the viral genome persists as high copy number, circular, non-integrated episomes which segregate to progeny upon cell division. This allows HVS-based vectors to stably transduce a dividing cell population and provide sustained transgene expression for an extended period of time both in vitro and in vivo. Moreover, the insertion of a bacterial artificial chromosome cassette into the HVS genome simplifies the incorporation of large amounts of heterologous DNA for gene delivery. Herein we have produced a recombinant HVS-based vector containing full-length human TRAIL under the control of the ?-survi…
MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors
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http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
Calcium carbonate microparticles used as a gene vector for delivering p53 gene into cancer cells.
April 29th, 2012In this study, CaCO(3) delivering pEGFP-C1-p53 could transfect about 5% of the tumor cells in culture. However, the efficiency of tumor cell apoptosis was surprisingly up to 80%. Meanwhile, the results of MTT assay and crystal violet staining showed that the CaCO(3) microparticles had low cytotoxicity. These findings showed that CaCO(3) microparticles were perspective to be used as new vectors for gene therapy. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
PMID: 22529011 [PubMed - as supplied by publisher] (Source: Cell Research)Source:
http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications
April 29th, 2012Molecular imaging is revolutionizing the way we study the inner workings of the human body, diagnose diseases, approach drug design, and assess therapies. The field as a whole is making possible the visualization of complex biochemical processes involved in normal physiology and disease states, in real time, in living cells, tissues, and intact subjects. In this review, we focus specifically on molecular imaging of intact living subjects. We provide a basic primer for those who are new to molecular imaging, and a resource for those involved in the field. We begin by describing classical molecular imaging techniques together with their key strengths and limitations, after which we introduce some of the latest emerging imaging modalities. We provide an overview of the main classes of molecul…Source:
http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
New Advanced Lens Technology with Postoperative LASIK Enhancement Has Cataract Patients Seeing Better than Ever
April 29th, 2012At Burgess and Mason Cosmetic and Family Dentistry, Drs. Jerry Burgess, D.D.S. and Scott Mason, D.D.S. now provide oral DNA screenings to test for both the cause of and genetic risk factors for periodontal diseases.Grapevine, TX (PRWEB) April 29, 2012 At Burgess and Mason Cosmetic and Family Dentistry, Drs. Jerry Burgess, D.D.S. and Scott Mason, D.D.S. now provide oral DNA screenings to test for …Source:
http://news.search.yahoo.com/news/rss?ei=UTF-8&p=genetic+therapy&eo=UTF-8
Research and Markets: Recent Advances in Cancer Research and Therapy – Increased Research on one of the Major Causes …
April 26th, 2012
DUBLIN–(BUSINESS WIRE)–
Research and Markets (http://www.researchandmarkets.com/research/msjp88/recent_advances_in) has announced the addition of Elsevier Science and Technology’s new report “Recent Advances in Cancer Research and Therapy” to their offering.
Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy. There is also a discussion of current cancer research in China including traditional Chinese medicine. Written by leading scientists in the field, this book provides an essential insight into the current state of cancer therapy and treatment.
Key Topics Covered:
1. Biotherapy of Cancer: Progress in China
2. Cancer Targeting Gene-Viro-Therapy (CTGVT) and Its Promising Future
3. Relationship Between Antiproliferative Activities and Class I MHC Surface Expression of Mouse Interferon Proteins on B16-F10 Melanoma Cells
4. Mitotic Regulator Hec1 as a Potential Target for Developing Breast Cancer Therapeutics
5. Advances in Liposome-based Targeted Gene Therapy of Cancer
6. Re-wiring the Intracellular Signaling Network in Cancer
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Research and Markets: Recent Advances in Cancer Research and Therapy – Increased Research on one of the Major Causes …
Will we ever correct diseases before birth? | Not Exactly Rocket Science
April 26th, 2012
Heres the sixth piece from my new BBC column
Every year, millions of people are born with debilitating genetic disorders, a result of inheriting just one faulty gene from their parents. They may have been dealt a dud genetic hand, but they do not have to stick with it. With the power of modern genetics, scientists are developing ways of editing these genetic errors and reversing the course of many hard-to-treat diseases.
These gene therapies exploit the abilities of viruses biological machines that are already superb at penetrating cells and importing genes. By removing their ability to reproduce, and loading them with the genes of our choice, we can transform viruses from causes of disease into vectors for cures.
After a few shaky starts, some of these approaches are beginning to hit their stride. Thirteen children with SCID, an immune disorder that leaves people fatally vulnerable to infections, now have working immune systems. Several British patients with haemophilia, which prevents their blood from clotting properly, can now produce a clotting protein called factor IX, which they once had to inject. A British man and three Americans with inherited forms of progressive blindness can see again.
It is still early days as far as trumpeting gene therapy cures are concerned, but even if they do succeed there is still one significant limitation that cannot be overlooked. Treating adults and children in this way will do for some disorders, but genetic disorders cause irreparable organ damage, or even death, very early. With some of the diseases that we look at, five years old is too late. Sometimes, you dont get to the age of five, says Simon Waddington from University College London. Every single one is a little bit niche but when you list them all out, theres quite a lot of them.
To treat such conditions, we need to intervene as early as possible, and this means correcting genetic disorders in the womb. There are advantages to such prenatal gene therapy. Organs that are hard to target after birth, such as airways blocked with mucus in cystic fibrosis patients, may be easier to reach in the womb. Being smaller, foetuses need a relatively smaller amount of delivery vector. And their immune systems are naive, so they are unlikely to mount an immune response to these vectors.
Risk assessment
So far, several teams have tested prenatal gene therapy in animals, including mice, monkeys and sheep. The results have been promising. In several cases, the animals produce decent levels of foreign proteins for many months, and their immune systems tolerate the added genes. Some have even been cured of their diseases.
Despite these successes, the research has reached an impasse. No one has tried prenatal gene therapy in humans, and no clinical trials are in the works. This is understandable. Altering a foetus genes is a sombre prospect, especially as gene therapy is still a relatively immature technology. It hasnt been embedded enough yet, says Waddington. If these treatments can prove their safety and effectiveness in adults, the field will move towards trials in newborn babies, and from there to prenatal tests.
For now, there are still many potential risks to address. Were still very much looking at which is the right vector to use, says Anna David, from University College London. Lentiviruses and retroviruses (such as HIV) shunt their genes into those of their host. They would seem to provide an ideal way of correcting a faulty gene, either by overwriting it, or providing a cell with working copies.
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Will we ever correct diseases before birth? | Not Exactly Rocket Science
Direct conversion in the heart: a simple twist of fate
April 22nd, 2012This study hints that a gene therapy approach for in-situ reprogramming may provide an alternative for generating new cardiomyocytes within failing hearts. (Source: The EMBO Journal AOP)Source:
http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
[World Report] Promising new era dawns for cystic fibrosis treatment
April 22nd, 2012The recent approval of a new drug and the start of a phase 2 gene therapy trial are creating excitement about future treatment possibilities for people with cystic fibrosis. Zöe Corbyn reports. (Source: LANCET)Source:
http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml
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