Stem Cells Used To Regrow Breasts – Video

January 28th, 2012 by Rastomi | No comments »


24-01-2012 09:59 CBS Early Morning Show discusses the use of adult adipose (from fat) stem cells to regrow breast tissue for use for both cosmetic reasons and reconstructive reasons as in the case of a mastectomy.

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Stem Cells Used To Regrow Breasts – Video

Need muscle for a tough spot? Turn to fat stem cells

January 28th, 2012 by Apagiogs | No comments »


In diseases like "http://www.physorg.com/tags/muscular+dystrophy/" rel="tag"
class="textTag" style="color: inherit; text-decoration: none;"
name="readabilityLink-1" id="readabilityLink-1">muscular
dystrophy
"readability-DoNotFootnote" style=
"color: inherit;">[1]
or a
"readability-DoNotFootnote" style=
"color: inherit;">[2]
, “ "http://www.physorg.com/tags/muscle/" rel="tag" class="textTag"
style="color: inherit; text-decoration: none;" name=
"readabilityLink-3" id="readabilityLink-3">muscle
"#readabilityFootnoteLink-3" class="readability-DoNotFootnote"
style="color: inherit;">[3]

begins to die and undergoes its normal wounding processes,”
said Engler, a "http://www.physorg.com/tags/bioengineering/" rel="tag" class=
"textTag" style="color: inherit; text-decoration: none;" name=
"readabilityLink-4" id=
"readabilityLink-4">bioengineering
"#readabilityFootnoteLink-4" class="readability-DoNotFootnote"
style="color: inherit;">[4]

professor at the Jacobs School of Engineering at UC San Diego.
“This damaged tissue is fundamentally different from a
mechanical perspective” than healthy tissue.

Transplanted rel="tag" class="textTag" style=
"color: inherit; text-decoration: none;" name=
"readabilityLink-5" id="readabilityLink-5">stem
cells
"readability-DoNotFootnote" style=
"color: inherit;">[5]
might be
able to replace and repair diseased muscle, but up to this
point the transplants haven’t been very successful in muscular
dystrophy patients, he noted. The cells tend to clump into hard
nodules as they struggle to adapt to their new environment of
thickened and damaged tissue.

Engler, postdoctoral scholar Yu Suk Choi and the rest of the
team think their fat-derived stem cells might have a better
chance for this kind of therapy, since the cells seem to thrive
on a stiff and unyielding surface that mimics the damaged
tissue found in people with MD.

In their study in the journal Biomaterials, the
researchers compared the development of bone marrow stem cells
and fat-derived stem cells grown on surfaces of varying
stiffness, ranging from the softness of brain tissue to the
hardness of bone.

Cells from the fat lineage were 40 to 50 times better than
their bone marrow counterparts at displaying the proper
proteins involved in becoming muscle. These proteins are also
more likely to “turn on” in the correct sequence in the
fat-derived cells, Engler said.

Subtle differences in how these two types of cells interact
with their environment are critical to their development, the
scientists suggest. The fat-derived cells seem to sense their
“niche” on the surfaces more completely and quickly than
marrow-derived cells. “They are actively feeling their
environment soon, which allows them to interpret the signals
from the interaction of cell and environment that guide
development,” Choi explained.

Perhaps most surprisingly, "http://www.physorg.com/tags/muscle+cells/" rel="tag" class=
"textTag" style="color: inherit; text-decoration: none;" name=
"readabilityLink-6" id="readabilityLink-6">muscle
cells
"readability-DoNotFootnote" style=
"color: inherit;">[6]
grown from
the fat stem cells fused together, forming myotubes to a degree
never previously observed. Myotubes are a critical step in
muscle development, and it’s a step forward that Engler and
colleagues hadn’t seen before in the lab.

The fused cells stayed fused when they were transferred to a
very stiff surface. “These programmed cells are mature enough
so that they don’t respond the environmental cues” in the new
environment that might cause them to split apart, Engler says.

Engler and colleagues will now test how these new fused cells
perform in mice with a version of muscular dystrophy. The cells
survive in an environment of stiff tissue, but Engler cautions
that there are other aspects of diseased tissue such as its
shape and chemical composition to consider. “From the
perspective of translating this into a clinically viable
therapy, we want to know what components of the environment
provide the most important cues for these "http://www.physorg.com/tags/cells/" rel="tag" class="textTag"
style="color: inherit; text-decoration: none;" name=
"readabilityLink-7" id="readabilityLink-7">cells
,” he
said.
"readability-DoNotFootnote" style=
"color: inherit;">[7]


Provided by University of California – San Diego ( "http://www.physorg.com/partners/university-of-california---san-diego/"
rel="news" style="color: inherit; text-decoration: none;" name=
"readabilityLink-8" id="readabilityLink-8">news
"#readabilityFootnoteLink-8" class="readability-DoNotFootnote"
style="color: inherit;">[8]
:
style="color: inherit; text-decoration: none;" name=
"readabilityLink-9" id="readabilityLink-9">web
"#readabilityFootnoteLink-9" class="readability-DoNotFootnote"
style="color: inherit;">[9]
)

References

  1. "Jump to Link in Article">^ "http://www.physorg.com/tags/muscular+dystrophy/" rel="tag"
    class="textTag" name="readabilityFootnoteLink-1" id=
    "readabilityFootnoteLink-1">muscular dystrophy

    (www.physorg.com)
  2. "Jump to Link in Article">^ "http://www.physorg.com/tags/heart+attack/" rel="tag" class=
    "textTag" name="readabilityFootnoteLink-2" id=
    "readabilityFootnoteLink-2">heart attack

    (www.physorg.com)
  3. "Jump to Link in Article">^ "http://www.physorg.com/tags/muscle/" rel="tag" class=
    "textTag" name="readabilityFootnoteLink-3" id=
    "readabilityFootnoteLink-3">muscle

    (www.physorg.com)
  4. "Jump to Link in Article">^ "http://www.physorg.com/tags/bioengineering/" rel="tag"
    class="textTag" name="readabilityFootnoteLink-4" id=
    "readabilityFootnoteLink-4">bioengineering

    (www.physorg.com)
  5. "Jump to Link in Article">^ "http://www.physorg.com/tags/stem+cells/" rel="tag" class=
    "textTag" name="readabilityFootnoteLink-5" id=
    "readabilityFootnoteLink-5">stem cells

    (www.physorg.com)
  6. "Jump to Link in Article">^ "http://www.physorg.com/tags/muscle+cells/" rel="tag" class=
    "textTag" name="readabilityFootnoteLink-6" id=
    "readabilityFootnoteLink-6">muscle cells

    (www.physorg.com)
  7. "Jump to Link in Article">^ "http://www.physorg.com/tags/cells/" rel="tag" class=
    "textTag" name="readabilityFootnoteLink-7" id=
    "readabilityFootnoteLink-7">cells

    (www.physorg.com)
  8. "Jump to Link in Article">^ "http://www.physorg.com/partners/university-of-california---san-diego/"
    rel="news" name="readabilityFootnoteLink-8" id=
    "readabilityFootnoteLink-8">news

    (www.physorg.com)
  9. "Jump to Link in Article">^ "http://www.ucsd.edu/portal/site/ucsd" target="_blank" name=
    "readabilityFootnoteLink-9" id=
    "readabilityFootnoteLink-9">web

    (www.ucsd.edu)

See the article here:
Need muscle for a tough spot? Turn to fat stem cells

Molecular test more accurate in predicting lung cancer survival

January 28th, 2012 by newfashionclothing | No comments »

Washington, Jan 27 : An available molecular test can predict the likelihood of death from early-stage lung cancer more accurately than conventional methods, according to a team of scientists.

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Molecular test more accurate in predicting lung cancer survival

Return to Spring Qigong by Master Li Junfeng, AOMA Graduate School of Integrative Medicine – Video

January 28th, 2012 by augzoobax | No comments »


22-11-2011 14:58 Qigong by Master Li Junfeng, Return to Spring, Sheng Zhen Movements by AOMA Austin In this free video presented by AOMA Graduate School of Integrative Medicine in Austin, Texas, Master Li Junfeng demonstrates the first qigong technique of this series, a movement that begins any qigong practice. You can follow along at home. In addition to the physical fitness benefits of most exercise routines (improved circulation, weight loss, etc.) Sheng Zhen Qigong also offers mental and spiritual benefits such as stress relief, a calm mind, and an ability to handle stressful or painful situations. Junfeng Li is perhaps best known as having been the head coach of the world-renowned Beijing Wushu (Martial Arts) Team and National Wushu Team of the People’s Republic of China. Under his leadership, the Beijing Wushu Team consistently won first place in national and international competitions for over 12 years, elevating the standards of excellence and quality worldwide. He is the principle teacher of Sheng Zhen Wuji Yuan Gong. Li also serves as special advisor to the World Academic Society of Medical Qigong and the Qigong Science Research Association of China. He has taught in more than 20 countries and has instructed at AOMA since 2002. AOMA Graduate School offers a master’s-level graduate program in acupuncture and Oriental medicine. AOMA also conducts more than 20000 patient visits annually in its student and professional clinics. AOMA includes traditional Asian mind-body practices

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Return to Spring Qigong by Master Li Junfeng, AOMA Graduate School of Integrative Medicine – Video

Nuvigil online – Video

January 28th, 2012 by NutMailia | No comments »


02-12-2011 15:54 Nuvigil online – link to online store drugshost.com Modafinil (Modalert) 200 mg / 100 mg Modalert enhances short-term memory and lets users stay awake for extended periods. Amazing quality of ampakines cheap nuvigil online no prescription buy nuvigil online modafinil buy nuvigil online…

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Nuvigil online – Video

GW Center for Integrative Medicine – Video

January 28th, 2012 by vejnadey | No comments »


26-01-2012 11:39 GW CIM: Dr. Pan and Dr. Kogan talk about Integrative Medicine and the Center

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GW Center for Integrative Medicine – Video

Junior Diabetes Gala – Video

January 28th, 2012 by Podrozyrak | No comments »


21-01-2012 23:03 The 2012 Junior Diabetes Foundation Hope Gala was held tonight at the Jackson Country Club.

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Junior Diabetes Gala – Video

Regina woman a walking miracle

January 28th, 2012 by missfema | No comments »

REGINA — For more than two years, Dionne and Graham Warner
hoped for a miracle — and when it finally arrived Tuesday, they
were numb.

Then euphoric.

“The doctor walked in with no file in his hand,” Graham said.
“I thought, ‘That’s strange.’ But he didn’t need a file to tell
us.”

The doctor told Dionne, “You continue to be my walking
miracle.”

Her Regina oncologist told them a recent positron emission
tomography (PET) scan done in Winnipeg shows the 46-year-old
woman has no trace of cancer and is in remission.

Since 1995, Dionne has waged wars on breast cancer, brain
cancer and two bouts of liver cancer. The couple’s latest
battle with cancer began in December 2009 when Dionne was
diagnosed with Stage 4 cancer in her lungs, bones and liver.
Her oncologist told her she was a week to 10 days away from
either being paralyzed or losing the use of her arms because of
tumours pressing on her spine.

After getting the PET scan results, the couple was in awe as
they walked past examination rooms at the Allan Blair Cancer
Centre.

“Those were the rooms we sat in how many times where we learned
she had cancer,” Graham said. “It was a very strange feeling
walking past those rooms with this freedom. And then we walked
past the packed chemo waiting room, and it felt like we were
prisoners being released from prison and at the same time
knowing that’s a pretty rare thing. The cancer clinic is great
and they’re doing everything they can, but we were conscious
that not too many people walk out of there with the news we
just got.”

The Warners consulted a doctor of natural medicine and, with
the blessing of her oncologist, Dionne started treatments in
Mexico which the couple call comprehensive because they
included chemotherapy.

“The doctor of natural medicine in Regina said, ‘Dionne, you
can walk, talk and move. If I were you, I would either get to
Germany or Mexico for treatment,’ ” she said.

On their first three-week trip to Tijuana, Dionne underwent
major hyperthermia treatment weekly. The process involved
removing her blood gradually and heating it to 43 degrees C.
The blood was passed through ultraviolet light to kill any
bacteria and then re-introduced into her body.

Heat weakens cancer cells, but does not harm healthy cells,
Graham said.

Besides taking vitamins and supplements, Dionne had
chemotherapy treatments and was on a diet that had no gluten,
carbohydrates or dairy products. Consequently, the slender
woman lost a lot of weight, which didn’t please her Regina
oncologist.

“When we explored going back (to Mexico) to try some stem cell
therapy, he was less enthused, but he still assisted me in
pursuing stem cell therapy,” Graham said.

On the couple’s second trip to the Mexican hospital, Dionne had
stem cell therapy. Graham explained a sample of the tumour was
taken, harvested in the lab and a vaccine was made. After a
hyperthermia treatment, Dionne received an injection of the
killer cells, which attacked the cancer.

Graham estimates the first Mexican treatments cost $28,000 US
and the second set were around $22,000 US. In addition, the
couple paid just under $2,700 for each Avastin treatment Dionne
received in Canada. Over two years, she had two to three
Avastin treatments a month.

“I think we’re under this perception that our medical system
pays for everything and will always look after us, but it
didn’t pay for the Avastin, which we think was very effective,”
Graham said. “It would be nice to see the comprehensive
treatment join the traditional.”

Dionne said the treatment worked for her, but emphasized that
every cancer case is unique.

“Dionne’s attitude is the foundation to work from,” Graham
said. “When you have such a positive attitude, you can really
build off of that in pursuing different treatments.”

Since word has spread on social media that Dionne is in
remission, the couple has received hundreds of messages and
emails. Many well wishes have come from people they have never
met, but who have read Never Leave Your Wingman, a book written
by Regina author Deana J. Driver that chronicles the couple’s
story of hope since Dionne was first diagnosed.

“Hope is everything,” Graham said.

“You’ve got to start with your inner self and come out saying,
‘I’m going to do my best to fight back and win this battle and
live life with no regrets,’ ” Dionne added.

"color: inherit; text-decoration: none;" name=
"readabilityLink-1" id=
"readabilityLink-1">pcowan@leaderpost.com
"#readabilityFootnoteLink-1" class="readability-DoNotFootnote"
style="color: inherit;">[1]

© Copyright (c) The Regina Leader-Post

The rest is here:
Regina woman a walking miracle

Aesthetic Plastic Surgery / Anti Aging Medicine: The Next Generation Symposium Attracts a World Class Faculty to New …

January 28th, 2012 by acouncanT | No comments »

NEW YORK, Jan. 26, 2012 /PRNewswire/
– The third "lw_1327577905_0">Aesthetic Plastic Surgery / Anti Aging
Medicine: The Next Generation Symposium will be held on July
20-22, 2012 at the Conrad New York, a new luxury complex
overlooking the Hudson River adjacent to One World Trade Center
tower. This interactive, multidisciplinary conference will
feature a world-class faculty presenting advancements in
aesthetic surgery, "lw_1327577905_3">cosmetic medicine and anti-aging
therapy from around the globe.

This year's symposium will
feature groundbreaking technologies from Europe, Latin America
and the U.S. in the emerging fields of id="lw_1327577905_4">regenerative medicine, stem cell
research, dermal fillers and volumizing agents,
neuromodulators, lasers, light, ultrasound and radiofrequency
based technologies and "lw_1327577905_1">aesthetic plastic surgery. The faculty
we have assembled represents top experts from plastic surgery,
dermatology, facial plastic and oculoplastic surgery, as well
as anti-aging medicine,” said Course Chairman "yshortcuts" id="lw_1327577905_2">Z. Paul Lorenc, M.D.,
F.A.C.S. “We are entirely focused on what is happening now,
what is coming next and what the future will bring.”

The prestigious international faculty
includes: William Adams, M.D., Robert Bard, M.D., Cheryl
Burgess, M.D., James Carraway, M.D., Steven Cohen, M.D., Sydney
Coleman, M.D., Joseph Eviatar, M.D., Steven Fagien, M.D.,
Rebecca Fitzgerald, M.D., Roy Geronemus, M.D., Christopher
Godek, M.D., Miles Graivier, M.D., Joseph Gryskiewicz, M.D.,
Geoffrey Gurtner, M.D., Christine Hamori, M.D., David Hidalgo,
M.D., Haideh Hirmand, M.D., Joseph Hunstad, M.D., Nolan Karp,
M.D., Jeffrey M. Kenkel, M.D., Brian Kinney, M.D., Wendy Lewis,
Z. Paul Lorenc, M.D., Alan Matarasso, M.D., Foad Nahai, M.D.,
Ivona Percec, M.D., Joel Pessa, M.D., Jason Pozner, M.D.,
Andrea Pusic, M.D., Sam Rizk, M.D., J. Peter Rubin, M.D., Neil
Sadick, M.D., Anthony Sclafani, M.D., Robert Silich, M.D.,
Henry M. Spinelli, M.D., Arthur Swift, M.D., Heidi Waldorf,
M.D., V. Leroy Young, M.D., and Sabine Zenker,
M.D. 

The 2012 program has been expanded to
include innovative workshops led by leading experts on social
media and marketing, laser lipolysis and body shaping, facial
rejuvenation with novel agents, advanced imaging systems, and
new techniques for fat grafting and platelet rich fibrin matrix
(PRFM). Live demonstrations of dermal fillers, volumizing
agents and neuromodulators injection techniques will be
featured.

About Aesthetic Plastic Surgery
& Anti-Aging Medicine: The Next Generation
– An
interdisciplinary approach to disseminating, teaching and
promoting the most advanced information and developments in the
fields of aesthetic plastic surgery and anti-aging medicine. In
view of the rapid pace in development of new technology and
techniques employed in these fields, collectively we feel that
it is critical that  new information is shared in an
efficient, unbiased, forward looking manner with the focus of
enhancing patient's safety and level of care.

For information about sponsorship
opportunities and early bird registration,
visit 
  "http://us.lrd.yahoo.com/_ylt=A2KLJnMi7yNPNTQAkANxzJpG;_ylu=X3oDMTFqMDgxZXM0BG1pdANBcnRpY2xlIEJvZHkEcG9zAzEEc2VjA01lZGlhQXJ0aWNsZUJvZHlBc3NlbWJseQ--;_ylg=X3oDMTJ0czR0MWNzBGludGwDY2EEbGFuZwNlbi1jYQRwc3RhaWQDMmU0OTI2MTEtM2ZmMC0zNTJiLTg5M2YtODA3ZDg3NGM0MjRkBHBzdGNhdANuZXdzBHB0A3N0b3J5cGFnZQR0ZXN0Aw--;_ylv=0/SIG=11ebgr7us/EXP=1328964642/**http%3A//www.nextgenmtg.org/"
target="_blank" style="color: inherit; text-decoration: none;"
name="readabilityLink-1" id=
"readabilityLink-1">http://www.nextgenmtg.org
"#readabilityFootnoteLink-1" class="readability-DoNotFootnote"
style=
"color: inherit;">[1]

Like us on "http://us.lrd.yahoo.com/_ylt=A2KLJnMi7yNPNTQAkQNxzJpG;_ylu=X3oDMTFqaWd2Ymg3BG1pdANBcnRpY2xlIEJvZHkEcG9zAzIEc2VjA01lZGlhQXJ0aWNsZUJvZHlBc3NlbWJseQ--;_ylg=X3oDMTJ0czR0MWNzBGludGwDY2EEbGFuZwNlbi1jYQRwc3RhaWQDMmU0OTI2MTEtM2ZmMC0zNTJiLTg5M2YtODA3ZDg3NGM0MjRkBHBzdGNhdANuZXdzBHB0A3N0b3J5cGFnZQR0ZXN0Aw--;_ylv=0/SIG=11igl8854/EXP=1328964642/**http%3A//www.facebook.com/apssny"
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  1. "Jump to Link in Article">^ "http://us.lrd.yahoo.com/_ylt=A2KLJnMi7yNPNTQAkANxzJpG;_ylu=X3oDMTFqMDgxZXM0BG1pdANBcnRpY2xlIEJvZHkEcG9zAzEEc2VjA01lZGlhQXJ0aWNsZUJvZHlBc3NlbWJseQ--;_ylg=X3oDMTJ0czR0MWNzBGludGwDY2EEbGFuZwNlbi1jYQRwc3RhaWQDMmU0OTI2MTEtM2ZmMC0zNTJiLTg5M2YtODA3ZDg3NGM0MjRkBHBzdGNhdANuZXdzBHB0A3N0b3J5cGFnZQR0ZXN0Aw--;_ylv=0/SIG=11ebgr7us/EXP=1328964642/**http%3A//www.nextgenmtg.org/"
    target="_blank" name="readabilityFootnoteLink-1" id=
    "readabilityFootnoteLink-1">http://www.nextgenmtg.org

    (us.lrd.yahoo.com)
  2. "Jump to Link in Article">^ "http://us.lrd.yahoo.com/_ylt=A2KLJnMi7yNPNTQAkQNxzJpG;_ylu=X3oDMTFqaWd2Ymg3BG1pdANBcnRpY2xlIEJvZHkEcG9zAzIEc2VjA01lZGlhQXJ0aWNsZUJvZHlBc3NlbWJseQ--;_ylg=X3oDMTJ0czR0MWNzBGludGwDY2EEbGFuZwNlbi1jYQRwc3RhaWQDMmU0OTI2MTEtM2ZmMC0zNTJiLTg5M2YtODA3ZDg3NGM0MjRkBHBzdGNhdANuZXdzBHB0A3N0b3J5cGFnZQR0ZXN0Aw--;_ylv=0/SIG=11igl8854/EXP=1328964642/**http%3A//www.facebook.com/apssny"
    target="_blank" name="readabilityFootnoteLink-2" id=
    "readabilityFootnoteLink-2">http://www.facebook.com/apssny

    (us.lrd.yahoo.com)
  3. "Jump to Link in Article">^ "http://us.lrd.yahoo.com/_ylt=A2KLJnMi7yNPNTQAkgNxzJpG;_ylu=X3oDMTFqaTNjbzlmBG1pdANBcnRpY2xlIEJvZHkEcG9zAzMEc2VjA01lZGlhQXJ0aWNsZUJvZHlBc3NlbWJseQ--;_ylg=X3oDMTJ0czR0MWNzBGludGwDY2EEbGFuZwNlbi1jYQRwc3RhaWQDMmU0OTI2MTEtM2ZmMC0zNTJiLTg5M2YtODA3ZDg3NGM0MjRkBHBzdGNhdANuZXdzBHB0A3N0b3J5cGFnZQR0ZXN0Aw--;_ylv=0/SIG=11ltph05l/EXP=1328964642/**http%3A//www.twitter.com/nextgenmtg"
    target="_blank" name="readabilityFootnoteLink-3" id=
    "readabilityFootnoteLink-3">http://www.twitter.com/nextgenmtg

    (us.lrd.yahoo.com)

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Aesthetic Plastic Surgery / Anti Aging Medicine: The Next Generation Symposium Attracts a World Class Faculty to New …

Ontario's first cardiac stem cell transplant performed last week

January 28th, 2012 by wheetuittar | No comments »


The first patient to receive this type of stem cell therapy,
James Culross, a 67-year-old man from Etobicoke, will be
discharged this week after 2.83 million "http://www.physorg.com/tags/stem+cells/" rel="tag" class=
"textTag" style="color: inherit; text-decoration: none;" name=
"readabilityLink-1" id="readabilityLink-1">stem
cells
"readability-DoNotFootnote" style=
"color: inherit;">[1]
were
injected into seven sites where his heart had been damaged by a
"readability-DoNotFootnote" style=
"color: inherit;">[2]
in November
2011. The stem cells were injected following "http://www.physorg.com/tags/coronary+artery+bypass+graft/"
rel="tag" class="textTag" style=
"color: inherit; text-decoration: none;" name=
"readabilityLink-3" id="readabilityLink-3">coronary artery
bypass graft
"readability-DoNotFootnote" style=
"color: inherit;">[3]
(CABG)
surgery, by a multi-disciplinary team led by Dr. Terrence Yau,
"tag" class="textTag" style=
"color: inherit; text-decoration: none;" name=
"readabilityLink-4" id="readabilityLink-4">Cardiac
Surgeon
"readability-DoNotFootnote" style=
"color: inherit;">[4]
and
Director of the Cardiac Stem Cell Therapy Program at the Peter
Munk Cardiac Centre. A second patient underwent successful stem
cell implantation and CABG surgery at the Peter Munk Cardiac
Centre this week.

“When a patient suffers a heart attack, part of the "http://www.physorg.com/tags/heart+muscle/" rel="tag" class=
"textTag" style="color: inherit; text-decoration: none;" name=
"readabilityLink-5" id="readabilityLink-5">heart
muscle
"readability-DoNotFootnote" style=
"color: inherit;">[5]
dies and is
replaced by scar. The larger the heart attack, the more likely
that patient is to develop "http://www.physorg.com/tags/heart+failure/" rel="tag" class=
"textTag" style="color: inherit; text-decoration: none;" name=
"readabilityLink-6" id="readabilityLink-6">heart
failure
"readability-DoNotFootnote" style=
"color: inherit;">[6]
, in which
the heart becomes progressively weaker. Patients develop
"tag" class="textTag" style=
"color: inherit; text-decoration: none;" name=
"readabilityLink-7" id="readabilityLink-7">shortness of
breath
"readability-DoNotFootnote" style=
"color: inherit;">[7]
, initially
during activity but later at rest as heart failure progresses,
and ultimately die of this disease,” says Dr. Yau, who holds
the Angelo & Lorenza DeGasperis Chair in Cardiovascular
Surgery Research.

After a diagnosis of severe heart failure, the average life
expectancy is one and a half years for men and three years for
women, a prognosis worse than most cancers. Current treatments
for heart attacks, including angioplasty, stenting and "http://www.physorg.com/tags/coronary+bypass+surgery/" rel=
"tag" class="textTag" style=
"color: inherit; text-decoration: none;" name=
"readabilityLink-8" id="readabilityLink-8">coronary bypass
surgery
"readability-DoNotFootnote" style=
"color: inherit;">[8]
, have saved
many lives and prevented further heart attacks, but they cannot
reverse the effect of heart attacks that have already occurred.
While researchers hope that stem cell therapy will improve the
function of hearts injured by heart attacks, the safety and
efficacy of stem cell therapy must first be clearly
demonstrated in "http://www.physorg.com/tags/clinical+trials/" rel="tag" class=
"textTag" style="color: inherit; text-decoration: none;" name=
"readabilityLink-9" id="readabilityLink-9">clinical
trials
"readability-DoNotFootnote" style=
"color: inherit;">[9]
such as the
IMPACT-CABG Trial.

Using a novel process, unique in Canada, in which stem cells
are isolated by means of a rigorously-tested process in the
University Health Network's Organ Regeneration Laboratory,
located entirely within operating room suite, researchers
removed, prepared and injected the stem cells back into the
patient on the same day.

“Manipulating the cells in-house preserves cell viability.
Injecting the stem cells into the heart as soon as possible
after they are isolated from the patient's "http://www.physorg.com/tags/bone+marrow/" rel="tag" class=
"textTag" style="color: inherit; text-decoration: none;" name=
"readabilityLink-10" id="readabilityLink-10">bone
marrow
"readability-DoNotFootnote" style=
"color: inherit;">[10]
may
improve their ability to improve heart function,” says Dr.
Richard Weisel, Cardiac Surgeon at the Peter Munk Cardiac
Centre and Senior Scientist at the McEwen Centre for
Regenerative Medicine.

Here's how the process works: 100 millilitres of bone marrow is
acquired the morning of the patient's bypass surgery from the
iliac crest – the flat portion of the hip bone located near the
lower back – which is rich in bone marrow. The bone marrow is
then brought to the Organ Regeneration Laboratory, where
research technicians use a clinical-grade magnetic separating
device called the CliniMACS to separate the CD133 stem cells
from other components of the bone marrow. During the stem cell
isolation procedure, which takes four to six hours, the patient
rests until their surgery, which is scheduled to begin in the
early afternoon.

The end result is two millilitres of clear fluid containing
several million stem cells that have been rigorously tested to
ensure that they pass Health Canada-approved release criteria.
The cells are brought in a sterile tube to the "http://www.physorg.com/tags/operating+room/" rel="tag" class=
"textTag" style="color: inherit; text-decoration: none;" name=
"readabilityLink-11" id="readabilityLink-11">operating
room
"readability-DoNotFootnote" style=
"color: inherit;">[11]
where Dr.
Yau's "http://www.physorg.com/tags/coronary+artery+bypass/" rel="tag"
class="textTag" style="color: inherit; text-decoration: none;"
name="readabilityLink-12" id="readabilityLink-12">coronary
artery bypass
"readability-DoNotFootnote" style=
"color: inherit;">[12]
graft
(CABG) surgery is underway. After the bypass grafts have been
completed, Dr. Yau fills a syringe with the stem cells and
injects them into the area of the heart that has been damaged
by a heart attack.

“This intraoperative approach to cardiac "http://www.physorg.com/tags/stem+cell+therapy/" rel="tag"
class="textTag" style="color: inherit; text-decoration: none;"
name="readabilityLink-13" id="readabilityLink-13">stem cell
therapy
"readability-DoNotFootnote" style=
"color: inherit;">[13]
is an
important component of the new Organ Regeneration Laboratory at
the University Health Network,” says Dr. Shaf Keshavjee,
Surgeon-in-Chief at UHN. “Whether it is repairing hearts or
lungs, the Organ Regeneration Laboratory is at the leading edge
of regenerative medicine.”

To date, over 500 heart patients worldwide have been treated
with a variety of stem cell preparations. Eight patients have
been treated at the Maisonneuve-Rosemont Hospital in Montreal
as part of the IMPACT-CABG Clinical Trial. Toronto and Montreal
researchers will merge their results after each centre performs
stem cell transplants in 20 patients. The objective of the
IMPACT-CABG Trial is to demonstrate the safety of injecting
stem cells into the hearts of patients undergoing CABG surgery,
and to gather information on the feasibility and efficacy of
this approach.

“This clinical trial marks an important milestone in
regenerative medicine therapy at the University Health Network
and paves the way for collaborative studies between scientists
at the McEwen Centre and Dr. Yau and the team at the Peter Munk
Cardiac Centre,” says Dr. Gordon Keller, Director of the McEwen
Centre for Regenerative Medicine.

Dr. Barry Rubin, Medical Director of the Peter Munk Cardiac
Centre, commented, “The Peter Munk Cardiac Centre is leading
innovation into new treatments for cardiovascular diseases. We
are very pleased to partner with scientists in the McEwen
Centre and to work together to provide novel stem cell
therapies for our patients.”


Provided by University Health Network

References

  1. "Jump to Link in Article">^ "http://www.physorg.com/tags/stem+cells/" rel="tag" class=
    "textTag" name="readabilityFootnoteLink-1" id=
    "readabilityFootnoteLink-1">stem cells

    (www.physorg.com)
  2. "Jump to Link in Article">^ "http://www.physorg.com/tags/heart+attack/" rel="tag" class=
    "textTag" name="readabilityFootnoteLink-2" id=
    "readabilityFootnoteLink-2">heart attack

    (www.physorg.com)
  3. "Jump to Link in Article">^ "http://www.physorg.com/tags/coronary+artery+bypass+graft/"
    rel="tag" class="textTag" name="readabilityFootnoteLink-3"
    id="readabilityFootnoteLink-3">coronary artery bypass
    graft
    (www.physorg.com)
  4. "Jump to Link in Article">^ "http://www.physorg.com/tags/cardiac+surgeon/" rel="tag"
    class="textTag" name="readabilityFootnoteLink-4" id=
    "readabilityFootnoteLink-4">Cardiac Surgeon

    (www.physorg.com)
  5. "Jump to Link in Article">^ "http://www.physorg.com/tags/heart+muscle/" rel="tag" class=
    "textTag" name="readabilityFootnoteLink-5" id=
    "readabilityFootnoteLink-5">heart muscle

    (www.physorg.com)
  6. "Jump to Link in Article">^ "http://www.physorg.com/tags/heart+failure/" rel="tag" class=
    "textTag" name="readabilityFootnoteLink-6" id=
    "readabilityFootnoteLink-6">heart failure

    (www.physorg.com)
  7. "Jump to Link in Article">^ "http://www.physorg.com/tags/shortness+of+breath/" rel="tag"
    class="textTag" name="readabilityFootnoteLink-7" id=
    "readabilityFootnoteLink-7">shortness of breath

    (www.physorg.com)
  8. "Jump to Link in Article">^ "http://www.physorg.com/tags/coronary+bypass+surgery/" rel=
    "tag" class="textTag" name="readabilityFootnoteLink-8" id=
    "readabilityFootnoteLink-8">coronary bypass surgery

    (www.physorg.com)
  9. "Jump to Link in Article">^ "http://www.physorg.com/tags/clinical+trials/" rel="tag"
    class="textTag" name="readabilityFootnoteLink-9" id=
    "readabilityFootnoteLink-9">clinical trials

    (www.physorg.com)
  10. "Jump to Link in Article">^ "http://www.physorg.com/tags/bone+marrow/" rel="tag" class=
    "textTag" name="readabilityFootnoteLink-10" id=
    "readabilityFootnoteLink-10">bone marrow

    (www.physorg.com)
  11. "Jump to Link in Article">^ "http://www.physorg.com/tags/operating+room/" rel="tag"
    class="textTag" name="readabilityFootnoteLink-11" id=
    "readabilityFootnoteLink-11">operating room

    (www.physorg.com)
  12. "Jump to Link in Article">^ "http://www.physorg.com/tags/coronary+artery+bypass/" rel=
    "tag" class="textTag" name="readabilityFootnoteLink-12" id=
    "readabilityFootnoteLink-12">coronary artery bypass

    (www.physorg.com)
  13. "Jump to Link in Article">^ "http://www.physorg.com/tags/stem+cell+therapy/" rel="tag"
    class="textTag" name="readabilityFootnoteLink-13" id=
    "readabilityFootnoteLink-13">stem cell therapy

    (www.physorg.com)

Continued here:
Ontario's first cardiac stem cell transplant performed last week

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